Patients with metabolic syndrome demonstrated early diastolic dysfunction, mitochondrial impairment, and microvascular disturbances contributing to fibrotic changes in the myocardium.
Observational
Metabolic syndrome is associated with early structural and functional myocardial changes, including diastolic dysfunction and fibrosis, underscoring the need for early diagnosis and treatment to prevent progression to heart failure.
This study aimed to evaluate early structural and functional myocardial changes in patients with metabolic syndrome. A clinico-morphological approach was applied, including anthropometric, biochemical, and echocardiographic assessments1,2,3. Insulin resistance was evaluated using the HOMA-IR index. The results demonstrated early diastolic dysfunction, mitochondrial impairment, and microvascular disturbances, contributing to fibrotic changes in the myocardium. These findings highlight the importance of early diagnosis and pathogenetic treatment to prevent progression to heart failure.
Nigoraxon Ravshanbek kizi Madraximova (Wed,) conducted a observational in Metabolic syndrome. Patients with metabolic syndrome demonstrated early diastolic dysfunction, mitochondrial impairment, and microvascular disturbances contributing to fibrotic changes in the myocardium.