Functionality-Matched Semicarbazone Reagents Allow Access to X-ray Quality Crystals and Solids of Diverse Organic Molecules

Key Points

• The study aims to develop a method for synthesizing crystalline compounds using semicarbazone reagents.
• Lipophilic structures were connected to semicarbazone reagents via copper-catalyzed azide-alkyne cycloaddition or acid-base reactions.
• Various lipophilic compounds, including esters and amines, were transformed into crystalline solids using these techniques.
• Crystalline nature was assessed by powder X-ray diffraction and further confirmed with single crystal X-ray diffraction.
• Crystalline solids were obtained with melting points ranging from 134 to over 240 °C.
• Single crystal X-ray diffraction indicated hydrogen-bond interactions enhancing crystal ordering.
• The approach demonstrated flexibility in accessing a range of organic molecules.