Dynamic proximity networks of myosin-19 (Myo19) and its mitochondrial receptors Miro2 and metaxin-3.

Key Points

• This research aims to explore the interactions between myosin-19 and its mitochondrial receptors Miro2 and metaxin-3.
• Utilized TurboID for proximity labeling to identify interacting proteins.
• Analyzed the dynamic networks formed by myosin-19 in relation to mitochondrial receptors.
• Conducted biochemical assays to confirm interactions.
• Identified significant interactions between myosin-19 and Miro2, indicating a role in mitochondrial dynamics.
• Observed a distinct proximity network involving metaxin-3 that relates to mitochondrial function.