Cytotoxicity and Immunogenic Cell Death Studies of Water-soluble Tetrahedral Ga(III) or Fe(III) Coordination Cages Containing a Au(I) Anticancer Drug as Guest

Key Points

• This research aims to evaluate the cytotoxicity and immunogenic cell death properties of water-soluble tetrahedral coordination cages incorporating Au(I) anticancer drugs.
• Investigated Ga(III) and Fe(III) coordination cages as carriers for Au(I) drugs.
• Assessed cytotoxicity and immunogenic cell death in vitro.
• Employed analytical techniques to evaluate the interaction between cages and drugs.
• Ga(III) cages demonstrated a significant increase in cytotoxicity against cancer cells compared to control (p<0.01).
• Immunogenic cell death was notably observed with FIN-ester in the presence of coordination cages (p<0.05).
• The efficacy of Au(I) drug delivery was enhanced by the tetrahedral structure, increasing therapeutic potential.