A 40-year-old woman with severe P. falciparum malaria and thrombosis carried ACE I/D and MTHFR polymorphisms, suggesting a potential role of these genetic variants in the clinical course.
Case Report (n=1)
No
Do ACE I/D and MTHFR polymorphisms influence the severity and thrombotic complications of P. falciparum malaria?
This case report highlights a potential association between ACE I/D and MTHFR polymorphisms and the severity and thrombotic complications of P. falciparum malaria.
Malaria, primarily caused by Plasmodium falciparum , remains a critical global health challenge, particularly in sub‐Saharan Africa. Genetic factors such as angiotensin‐converting enzyme (ACE) I/D polymorphism have been implicated in influencing malaria severity and outcomes. We report the case of a 40‐year‐old woman from Seychelles, residing in Ivory Coast, who developed severe P. falciparum malaria complicated by thrombosis. Laboratory findings revealed hyperparasitemia, acute kidney injury, and metabolic acidosis. Genetic testing through real time PCR identified the ACE I/D polymorphism, along with other thrombophilic variants such as MTHFR C677T and A1298C, suggesting a potential role in clinical course. This case aims to contribute to the debate about the role of ACE polymorphisms in malaria severity. Comprehensive studies are warranted to explore the genetic landscape in malaria‐endemic regions and its implications for personalized treatment strategies.
Pisapia et al. (Thu,) conducted a case report in Severe P. falciparum malaria (n=1). A 40-year-old woman with severe P. falciparum malaria and thrombosis carried ACE I/D and MTHFR polymorphisms, suggesting a potential role of these genetic variants in the clinical course.