De novo Microbial Production of Picolinic Acid via a Short-Cut Biosynthetic Pathway

Key Points

• This research explores the microbial production of picolinic acid through an innovative biosynthetic pathway.
• Developed a microbial system for producing picolinic acid from tryptophan.
• Optimized the biosynthetic pathway for increased yields.
• Conducted comparative analyses of the produced compound's properties.
• Achieved a significant increase in picolinic acid yields compared to traditional methods.
• Demonstrated enhanced metal-chelating properties of the produced picolinic acid.
• Showed broad antimicrobial and antiviral activities of the compound.