Does atrial fibrillation simulation increase ventricular proarrhythmic mechanisms?
This study provides mechanistic insights showing that atrial fibrillation promotes ventricular arrhythmogenesis, likely involving calmodulin-dependent protein kinase II oxidation.
/calmodulin-dependent protein kinase II oxidation did not develop ventricular proarrhythmic activity after AF simulation. This study demonstrates that AF promotes ventricular arrhythmogenesis. The findings offer new mechanistic insights into the interaction of AF and ventricular arrhythmias.
Spangler et al. (Fri,) studied this question.