Chemical constituents and ferroptosis inhibitory activity of the deep-sea-derived fungus Penicillium citrinum W24

Key Points

• Investigate the chemical constituents of Penicillium citrinum W24 and their inhibitory effects on ferroptosis.
• Isolated and characterized new citrinin derivatives from Penicillium citrinum W24.
• Conducted assays to evaluate ferroptosis inhibition of isolated compounds in vitro.
• Identified a new citrinin derivative with significant ferroptosis inhibitory activity.
• Demonstrated antioxidant properties of the compounds, supporting their therapeutic potential.