Host metabolism shapes the intestinal microbiota: a top-down paradigm of environmental selection pressure

Key Points

• Investigating how host metabolism influences the composition of the intestinal microbiota and dysbiosis.
• Utilized agonists and ketogenic diets to assess changes in host microbiota composition.
• Monitored the ecological filtration capacity of the host in response to dietary interventions.
• Dietary interventions positively altered microbiota composition, indicating improved dysbiosis management.
• Melatonin was effective in enhancing ecological filtration capacity, showing significant shifts in microbiota diversity.