Green Antibacterial-Antioxidant Hydrogel for Infected Wound Healing: Tea Polyphenol and Biosynthesized Silver Nanoparticles in a Deacetylated Sphingan WL Matrix

Key Points

• This research aims to develop a green hydrogel that aids in wound healing through antioxidant and antibacterial properties.
• Developed a polysaccharide-based hydrogel using tea polyphenols and biosynthesized silver nanoparticles.
• Assessed wound closure rates and tissue repair quality in an infected wound model over 14 days.
• Evaluated properties such as pH-responsiveness and controlled release characteristics.
• Wound closure achieved 78.2% at day 7 and 95.3% at day 14.
• The hydrogel promoted enhanced collagen deposition and minimal scarring during tissue repair.
• Demonstrated effective management of infected wounds via integrated therapeutic strategy.