What question did this study set out to answer?

This research aims to optimize the recovery and purification process of adeno-associated viruses (AAV) for gene therapies.

May 10, 2026Lab on a Chip0 citations

High-recovery AAV clarification using a multiplexed spiral inertial microfluidic platform

ABAlexander BevacquaMassachusetts Institute of Technology DPDo Hyun ParkMassachusetts Institute of Technology SKSheryar KhanCenter for Genomic Science

Key Points

This research aims to optimize the recovery and purification process of adeno-associated viruses (AAV) for gene therapies.
Utilized a multiplexed spiral inertial microfluidic platform for viral vector clarification.
Employed advanced bioprocessing techniques for high-recovery harvesting.
Achieved a significantly higher recovery rate of AAV compared to traditional methods, with a notable improvement in purification efficiency.

Abstract

The clinical adoption of emerging cell and gene therapies relies on the efficient upstream bioprocessing and high-recovery harvesting of viral vectors. AAV purification from cell culture begins with the removal...

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