Watercress (Eruca vesicaria) is a rich source of secondary metabolites with disease-preventive properties, including the phenol apigenin. This work aimed to examine the impact of various extraction methods on apigenin yield from watercress (Eruca vesicaria L.) leaves and its antioxidant capacity/blood coagulant effect. Organisations compared modern with traditional extraction methods. Active compounds identification and overall qualitative chemical analysis proved that the extract is rich in flavonoids, phenols, and terpenes. The selected solvent and the method of extraction had a remarkable impact on both yield and purity of apigenin. Free radical scavenging ability of saliva and phenolic content were also found high and these values were correlated, suggesting that its phenols may significantly contribute for the high oxidative activity. The results of this study further showed that apigenin is involved in modulating the blood coagulation system via prolonging prothrombin time (PT) and activating activated partial thromboplastin time (aPTT). This indicates that Ap inhibits intrinsic as well extrinsic coagulation paths. These results suggest that the leaves of E. vesicaria represent a rich source of apigenin, which may be used as potential phytochemicals in nutraceutical and cardiovascular disorders related to oxidative stress and thrombosis-induced diseases prevention.
Nabaa Qais Jameel (Sun,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: