Variants at 8p21.3 Mediate BMP1 Expression, Contributing to Higher Atopic Dermatitis Risk

Key Points

• The study aims to investigate the role of variants at 8p21.3 in BMP1 expression and its connection to atopic dermatitis susceptibility.
• Identified 8p21.3 polymorphisms associated with BMP1 expression levels.
• Examined BMP1 promoter activity in dermal fibroblasts.
• Assessed the correlation between BMP1 expression and skin hydration.
• Variants at 8p21.3 were linked to lower BMP1 expression.
• Lower BMP1 expression correlated with reduced skin hydration.
• Increased susceptibility to atopic dermatitis was observed with these variants.