This research aims to explore the neuroprotective properties of Elesestriterpenoid A from Eleutherococcus sessiliflorus leaves.
In vitro cell culture using HT22 cells to assess the effects of Elesestriterpenoid A.
Evaluation of oxidative damage mitigation through the Keap1/Nrf2/HO-1 signaling pathway.
Elesestriterpenoid A effectively reduced oxidative damage in HT22 cells.
Activation of the Keap1/Nrf2/HO-1 signaling pathway was confirmed as a mechanism of action.
Abstract
demonstrated pronounced efficacy in mitigating oxidative damage through modulation of the Keap1/Nrf2/HO-1 signaling pathway in HT22 cells, indicating its potential for treating nerve injuries.