What question did this study set out to answer?

This review aims to synthesize knowledge on the cerebral aqueduct's anatomy, molecular pathways, and surgical approaches related to congenital hydrocephalus.

May 10, 2026Anatomy & Cell Biology0 citations

Comprehensive review of the cerebral aqueduct: anatomy, embryology, imaging, genetics, molecular, and pathology

GDGabrielle Dituri NKNoritaka Komune NONicolás E. Ottone

Key Points

This review aims to synthesize knowledge on the cerebral aqueduct's anatomy, molecular pathways, and surgical approaches related to congenital hydrocephalus.
Conducted a literature review on the anatomy, embryology, imaging, and genetics of the cerebral aqueduct.
Critically appraised surgical strategies such as endoscopic third ventriculostomy and aqueductoplasty.
Evaluated efficacy, complications, and long-term outcomes of these interventions.
Highlighted the role of mutations and molecular pathways in congenital hydrocephalus.
Critically assessed surgical strategies revealing varying efficacy and complication profiles.
Identified significant knowledge gaps in the understanding of the cerebral aqueduct's role.

Abstract

mutations and broader molecular pathways implicated in congenital hydrocephalus. Surgical strategies, including endoscopic third ventriculostomy, aqueductoplasty, and transaqueductal stenting, are critically appraised in terms of efficacy, complication profiles, and long-term outcomes. Overall, this review underscores the CA as a nexus of neurodevelopment, neuropathology, and neurosurgical innovation, and identifies gaps in knowledge that merit future investigation.

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