Breast cancer exhibits multiple mechanisms of immune escape, including stromal exclusion, impaired antigen accessibility, dysfunctional lymphatic immune coordination and T-cell exhaustion. Although immune checkpoint inhibitors have demonstrated benefit in selected subtypes such as triple-negative breast cancer (TNBC), many tumours remain immunologically “cold” and resistant to effective immune infiltration. These observations suggest that insufficient tumour–immune synchronization may represent a major barrier to anti-tumour immunity. We propose the RGF framework (Ready–Go–Fever) as a three-step immunophysiological strategy designed to restore functional tumour–immune interaction in breast cancer. In this model, the “Ready” phase aims to establish a permissive immune environment through antigen preparation, lymphatic coordination and immune cell recruitment. The “Go” phase introduces controlled tumour disruption to enhance tumour antigen exposure and local release of damage-associated molecular patterns (DAMPs). The subsequent “Fever” phase is hypothesized to amplify systemic immune activation through synchronized inflammatory and lymphatic signalling, thereby promoting effective T-cell-mediated tumour clearance.
Li Chung Lee (Fri,) studied this question.