What question did this study set out to answer?

The research aims to examine the emergence of K. pneumoniae strains with PBP3 insertions linked to increased resistance.

May 11, 2026Emerging infectious diseases0 citationsOpen Access

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Emergence of Klebsiella pneumoniae Carbapenemase–Producing K. pneumoniae with Penicillin-Binding Protein 3 Insertions, Taiwan, 2021

TLTengfei Long ALArianne Lovey LSLillie Sanborn

Key Points

The research aims to examine the emergence of K. pneumoniae strains with PBP3 insertions linked to increased resistance.
Identified high-risk K. pneumoniae clones with PBP3 insertions
Assessed the mechanisms of β-lactam resistance
Emphasized the need for genomic surveillance and novel therapeutic strategies
Emergence of PBP3 insertions in K. pneumoniae was observed
These insertions are associated with significant resistance to β-lactam antibiotics
Findings highlight the urgent need for enhanced monitoring and new treatments for K. pneumoniae infections

Abstract

and other β-lactamases, contributes to reduced susceptibility. Those findings demonstrate the emergence of a PBP3 insertion in a high-risk K. pneumoniae clone, underscoring the expansion of this resistance mechanism and the critical need for genomic surveillance and novel therapeutics to identify and treat such infections.

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Emergence of Klebsiella pneumoniae Carbapenemase–Producing K. pneumoniae with Penicillin-Binding Protein 3 Insertions, Taiwan, 2021

Key Points

Abstract

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