Oxygen–Oxygen Bond-Forming Reactions for the Synthesis of Cyclic Peroxides

Key Points

• The research aims to explore reactions that form oxygen-oxygen bonds to create cyclic peroxides with retention of configuration at carbon atoms.
• Conducted O-labeling experiments to track the reaction process.
• Evaluated the reaction yields at -78 °C across various substrates, including five- and six-membered cyclic compounds.
• Analyzed the retention of configuration at the carbon centers in the resultant ring structures.
• The reaction was rapid and achieved high yields under the tested conditions.
• Successful synthesis of both five-membered and six-membered cyclic peroxides was demonstrated.
• The findings suggest this process mimics natural oxygen-oxygen bond formation.