A preliminary in-vitro and in-silico investigation into the cytotoxic and anti-metastatic activity of Smilax ovalifolia Roxb. ex D.Don against non-small cell lung cancer cells

Key Points

• This research investigates the cytotoxic and anti-metastatic activities of Smilax ovalifolia against non-small cell lung cancer cells.
• Conducted in-vitro assays to assess cytotoxicity and anti-metastatic effects.
• Performed in-silico analysis to evaluate compound binding stability with MMP-2.
• Stable binding of robinetin to MMP-2 was observed, indicating its role in anti-metastatic activity.
• Extracts from Smilax ovalifolia demonstrated significant cytotoxic effects on lung cancer cells.