What is the clinical evidence from this study?

Study design: Editorial. Population: Acute heart failure.

February 28, 2026Intensive Care Medicine0 citationsOpen Access

The creatinine conundrum in heart failure: rethinking AKI definitions

Key Result

Small creatinine rises during decongestion or medical therapy in acute heart failure often reflect functional changes rather than structural kidney injury and should not prompt therapy withdrawal.

PICO

Population

Acute heart failure

Limitations

Systematic biopsy data are lacking to definitively prove the absence of acute tubular necrosis in heart failure.
The proposed approach of differentiating functional from structural AKI using renal venous Doppler requires validation in randomized trials.
The incremental value of CA125 combined with urinary biomarkers has not been established.

问 AI

Bookmark

View Full Paper

问 AI

Bookmark

View Full Paper

Cite This Study

Husain-Syed et al. (Thu,) conducted a editorial in Acute heart failure. Small creatinine rises during decongestion or medical therapy in acute heart failure often reflect functional changes rather than structural kidney injury and should not prompt therapy withdrawal.

synapsesocial.com/papers/6a025a519cddff7633412b36 https://doi.org/https://doi.org/10.1007/s00134-025-08261-w