What is the clinical evidence from this study?

Study design: Other. Population: Mitral valve disease requiring re-intervention. Intervention: Valve-in-Valve/Ring TMVR vs. Re-Do Mitral Valve Surgery. Primary outcome: 5-Year Mortality.

February 28, 2026

Similar Periprocedural Safety and Efficacy, But Higher 5-Year Mortality Following Valve-in-Valve/Ring TMVR Compared to Re-Do Mitral Valve Surgery

Key Result

Valve-in-Valve/Ring TMVR demonstrated similar periprocedural safety and efficacy but higher 5-year mortality compared to re-do mitral valve surgery.

Structured PICO

Does Valve-in-Valve/Ring TMVR improve periprocedural safety and efficacy and 5-year mortality compared to Re-Do Mitral Valve Surgery?

Intervention

Valve-in-Valve/Ring Transcatheter Mitral Valve Replacement (TMVR)

Comparator

Re-Do Mitral Valve Surgery

Outcome

Periprocedural safety and efficacy, and 5-year mortality

Valve-in-Valve/Ring TMVR shows similar periprocedural safety and efficacy but higher 5-year mortality compared to re-do mitral valve surgery.

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Cite This Study

Gaekel et al. (Thu,) conducted a other in Mitral valve disease requiring re-intervention. Valve-in-Valve/Ring TMVR vs. Re-Do Mitral Valve Surgery was evaluated on 5-Year Mortality. Valve-in-Valve/Ring TMVR demonstrated similar periprocedural safety and efficacy but higher 5-year mortality compared to re-do mitral valve surgery.

synapsesocial.com/papers/6a025a979cddff7633412dbe https://doi.org/https://doi.org/10.1055/s-0046-1817345