What is the clinical evidence from this study?

Study design: Other. Population: Hypertension (n=7). Intervention: EMD 58265 vs. Enalaprilat (2 mg/kg IV). Primary outcome: Arterial blood pressure and renal blood flow.

What question did this study set out to answer?

This research aims to compare the effects of renin inhibition versus ACE inhibition on blood pressure and renal blood flow.

February 28, 2026

Renin-Angiotensin System

Key Result

The renin inhibitor EMD 58265 produced greater hypotension than the ACE inhibitor enalaprilat in anesthetized rabbits, which was associated with decreased plasma AI but not AII.

Key Points

This research aims to compare the effects of renin inhibition versus ACE inhibition on blood pressure and renal blood flow.
Compared arterial blood pressure and renal blood flow effects of EMD 58265 and enalaprilat in anesthetized rabbits.
Used electromagnetic flowmetry to measure renal blood flow in pooled data from hypertensive and normotensive rabbits.
Greater hypotension observed with renin inhibition (mean BP change 32.4 mmHg) compared to enalaprilat (mean BP change 22.2 mmHg).
Renal blood flow increased more with renin inhibition, impacting plasma Angiotensin I levels.

Structured PICO

Does the renin inhibitor EMD 58265 compared to enalaprilat affect arterial blood pressure and renal blood flow differently in anesthetized rabbits?

Population

7 New Zealand White rabbits anesthetized with sodium pentobarbital (pooled data from 5 2-kidney one-clip Goldblatt hypertensive and 2 normotensive rabbits)

Intervention

Renin inhibitor EMD 58265 (2-2.5 mg/kg IV)

Comparator

ACE inhibitor enalaprilat (2 mg/kg IV)

Outcome

Arterial blood pressure (BP) and renal blood flow (RBF)surrogate

In a rabbit model, renin inhibition caused greater hypotension than ACE inhibition, associated with decreased plasma AI but not AII.

Abstract

GREATER HYPOTENSIONDURINGRENIN THAN ACEINHIBITIONASSOCIATEDWITHDECREASED PLASMAAI, BUT NOT AIL Zimmerman*& PC Birt.Universityof Minnesota,Minneapolis,MN 55455. Hollenberg and Fisber (Hypertension 26:602-609, 1995) prwented evidence for a greater increase in renal plasmaflow witbthe administrationof reninthanACE inhibitors.This provocativeresult promptedus to compare the arteriatbloodpressure(BP)and renal bloodflow (RBF) effects of the renininhibitor,EMD 58265 (2-2.5 mgkg) and enalaprilat(2 mgkg) given IV in the anesthetized rabbit. BP, RBF (by electromagnetic flowmetry), and plasma AI and AfI levels were measured in New Zealand White rabbits anesthetizedwith sodiumpentobarbitsLThe data from5 2-lddneyone-clipGoldblatt hypertensive and2 normotmrsive rabbitswerepooled. EMR BP (mmHe) 107+12 89i9t 75*1O* ft#JIll&) 37k6 4(MI0 32*4 1007+676 1923*865 32*4* .., AII (P@td) 381*189 222k145f 440*354

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Discussion

Cite this study

A Thu, study conducted a other in Hypertension (n=7). EMD 58265 vs. Enalaprilat (2 mg/kg IV) was evaluated on Arterial blood pressure and renal blood flow. The renin inhibitor EMD 58265 produced greater hypotension than the ACE inhibitor enalaprilat in anesthetized rabbits, which was associated with decreased plasma AI but not AII.

synapsesocial.com/papers/6a025ac49cddff7633412e63 — DOI: https://doi.org/10.1080/17447658.1992.12561051

Renin-Angiotensin System

Key Result

Key Points

Structured PICO

Abstract

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Discussion

Cite this study

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