What is the clinical evidence from this study?

Study design: Other. Population: Myocardial infarction (n=24). Intervention: Left anterior descending (LAD) coronary artery ligation vs. Sham surgery. Primary outcome: Histological characterization of fibrotic remodeling and cardiac function (p=<0.05).

What question did this study set out to answer?

This research aims to characterize the histological changes occurring in cardiac tissue following an infarction in an animal model.

March 31, 2026Korean Journal of Clinical Laboratory Science0 citationsOpen Access

Histological Characterization of Post-infarction Cardiac Remodeling in an Animal Model

Q: What are the key findings of this study?

Left anterior descending coronary artery ligation in rats significantly impaired cardiac function and induced progressive fibrotic remodeling, characterized by cardiomyocyte apoptosis and collagen deposition.

Q: What question did this study set out to answer?

This research aims to characterize the histological changes occurring in cardiac tissue following an infarction in an animal model.

SJSeung Hwan Jeon

Key Result

Left anterior descending coronary artery ligation in rats significantly impaired cardiac function and induced progressive fibrotic remodeling, characterized by cardiomyocyte apoptosis and collagen deposition.

Key Points

This research aims to characterize the histological changes occurring in cardiac tissue following an infarction in an animal model.
Utilized an animal model of post-infarction cardiac remodeling for histological analysis.
Employed tissue staining and microscopic examination to assess structural changes.
Observed significant histological alterations in cardiac tissue post-infarction, indicating remodeling.
Characterized specific cellular and tissue changes that suggest pathways for potential therapeutic interventions.

Structured PICO

Population

24 male Sprague-Dawley rats (12 weeks old, 300-350 g)

Intervention

Myocardial infarction induced by permanent ligation of the left anterior descending (LAD) coronary artery

Comparator

Sham surgery (same surgical procedures without LAD ligation)

Outcome

Histological characterization of post-infarction myocardial remodeling (collagen deposition, cardiomyocyte integrity, apoptosis, collagen remodeling, microvascular alterations) and cardiac function at 4 weekssurrogate

This study provides integrated histological evidence that post-infarction remodeling is a progressive process involving cardiomyocyte apoptosis, active collagen remodeling, and microvascular disruption, suggesting potential stage-specific therapeutic windows.

Main Result

p-value: p=<0.05

Limitations

Focused primarily on histological characterization and did not include direct molecular or mechanistic analyses of fibrosis signaling pathways.
The rat MI model may not fully recapitulate all aspects of human MI and post-infarction fibrosis.

Abstract

Seung Hwan JEON. Korean J Clin Lab Sci 2026;58:30-40. https://doi.org/10.15324/kjcls.2026.58.1.30

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Cite This Study

Seung Hwan Jeon (Tue,) conducted a other in Myocardial infarction (n=24). Left anterior descending (LAD) coronary artery ligation vs. Sham surgery was evaluated on Histological characterization of fibrotic remodeling and cardiac function (p=<0.05). Left anterior descending coronary artery ligation in rats significantly impaired cardiac function and induced progressive fibrotic remodeling, characterized by cardiomyocyte apoptosis and collagen deposition.

synapsesocial.com/papers/6a025bf2edf6f48138594171 https://doi.org/https://doi.org/10.15324/kjcls.2026.58.1.30

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