Compared with aspirin monotherapy, dual antiplatelet therapy reduced the risk of in-hospital stroke or death after carotid endarterectomy (RR 0.79), albeit with higher bleeding complications.
Cohort (n=216,615)
Yes
Does preoperative clopidogrel or DAPT reduce in-hospital stroke or death compared to aspirin alone in patients undergoing carotid endarterectomy?
In patients undergoing carotid endarterectomy, preoperative clopidogrel monotherapy and DAPT were associated with lower in-hospital stroke or death compared to aspirin alone, though DAPT significantly increased bleeding complications.
Effect estimate: RR 0.79 (95% CI 0.72-0.87)
Absolute Event Rate: 1.2% vs 1.3%
Park et al. (Mon,) conducted a cohort in Carotid artery stenosis undergoing carotid endarterectomy (n=216,615). Dual antiplatelet therapy (ASA/clopidogrel) vs. Aspirin (ASA) only was evaluated on In-hospital stroke/death (RR 0.79, 95% CI 0.72-0.87). Compared with aspirin monotherapy, dual antiplatelet therapy reduced the risk of in-hospital stroke or death after carotid endarterectomy (RR 0.79), albeit with higher bleeding complications.