Left bundle branch area antitachycardia pacing terminated ventricular tachycardia more often than right ventricular pacing (70.2% vs 47.3%; P=0.040) in a preclinical animal model.
Does burst antitachycardia pacing delivered to the left bundle branch area improve ventricular tachycardia termination compared to right ventricular pacing in an animal model of ischemia-reperfusion injury?
In a preclinical model, antitachycardia pacing delivered to the left bundle branch area was more effective at terminating ventricular tachycardia than conventional right ventricular pacing.
Absolute Event Rate: 70.2% vs 47.3%
p-value: p=0.040
BACKGROUND Antitachycardia pacing (ATP) therapy applies a sequence of pacing pulses to terminate ventricular tachycardia (VT). Clinically, left bundle branch area (LBBA) pacing has emerged as a novel way to induce synchronous ventricular activation. OBJECTIVES The main aim of this study was to compare the efficacy and safety of ATP delivered to an LBBA lead and a conventional right ventricular (RV) lead. METHODS Using a preclinical animal model (n = 7), pacing leads were implanted in the RV apex and LBBA and connected to implantable cardioverter-defibrillators. The left anterior descending artery was occluded for 2 hours to cause an ischemia-reperfusion injury. Four days following ischemia-reperfusion injury, VT episodes were induced using programmed pacing, and burst ATP therapy was delivered to the RV/LBBA leads for each VT episode. Activation sequences from an implanted basket catheter were determined for the pretherapy VT and ATP beats. RESULTS VT was induced 80 times, with a mean VT cycle length of 180.0 ± 30.0 milliseconds. ATP delivered to the LBBA terminated VT more often than RV ATP (70.2% vs 47.3%; P = 0.040). There was no significant difference in VT acceleration or ventricular fibrillation induction. The number of ATP pulses required for the activation sequences to correlate with the captured ATP pattern rather than the pretherapy VT pattern was lower for LBBA compared to RV ATP (4.1 vs 5.1 pulses; P = 0.047). CONCLUSIONS Improved performance of LBBA compared to RV ATP provides an incentive for future clinical studies in patients who are at risk of sudden cardiac death.
Offei et al. (Sun,) conducted a other in Ventricular tachycardia (n=7). Left bundle branch area (LBBA) antitachycardia pacing vs. Right ventricular (RV) antitachycardia pacing was evaluated on Termination of ventricular tachycardia (p=0.040). Left bundle branch area antitachycardia pacing terminated ventricular tachycardia more often than right ventricular pacing (70.2% vs 47.3%; P=0.040) in a preclinical animal model.