Isolated TAVR was associated with a significantly higher risk of death between 2 and 5 years (HR 1.69) compared to surgical aortic valve replacement with coronary artery bypass grafting.
Does TAVR compared to SAVR with CABG improve outcomes in patients with severe coronary artery disease and aortic stenosis?
While TAVR offers early safety benefits such as reduced perioperative stroke, SAVR combined with CABG remains the benchmark for better long-term survival in patients with severe aortic stenosis and concurrent severe coronary artery disease who are not at high surgical risk.
Effect estimate: HR 1.69 (95% CI 1.05-2.70)
p-value: p=0.03
Manoly et al. (Thu,) conducted a letter in Severe coronary artery disease and aortic stenosis. Transcatheter Aortic Valve Replacement (TAVR) vs. Surgical Aortic Valve Replacement (SAVR) and Coronary Artery Bypass Grafting (CABG) was evaluated on Death between 2 and 5 years (HR 1.69, 95% CI 1.05-2.70, p=0.03). Isolated TAVR was associated with a significantly higher risk of death between 2 and 5 years (HR 1.69) compared to surgical aortic valve replacement with coronary artery bypass grafting.