• Strategies to enhance phytonutrient content, stability, and efficacy were reviewed. • Genetic engineering and precision farming approaches were critically discussed. • Applications of nanomaterials to improve phytonutrient delivery were highlighted. • Challenges regarding regulation, ethics, and sustainability were identified. • Future directions for interdisciplinary collaboration were recommended. This review highlights innovative strategies aimed at increasing the content, stability, and efficacy of phytonutrients in food systems. Key approaches include genetic engineering to enhance biosynthetic pathways in crops, precision farming to optimize environmental conditions for phytochemical production, and the use of nanomaterials to improve phytonutrient stability, bioavailability, and absorption. Case studies and practical applications demonstrate the transformative potential of these technologies in both agriculture and food processing. Recent progress in computational and data-driven tools is opening new opportunities for personalized nutrition, enabling the tailoring of phytonutrient intake to individual health needs. At the same time, the implementation of these emerging approaches faces important challenges, including regulatory constraints, ethical considerations, economic limitations, and the need for long-term safety and sustainability assessments. Addressing these issues will require strong interdisciplinary collaboration, effective knowledge sharing, and closer integration of scientific research, policy development, and industrial application. Continued technological innovation will be essential to fully realize the potential of phytonutrient enhancement in supporting healthier and more sustainable food systems. By harnessing these technological advances, phytonutrient research is positioned to play a key role in promoting healthier populations, supporting plant-based diets, and contributing to more sustainable and resilient food systems.
Silva et al. (Fri,) studied this question.