Ginsenoside Rg5 Ameliorates Ferroptosis in Ethanol‐Induced Acute Liver Injury by Activating FTO ‐ YTHDF2 ‐Nrf2 Signal

Key Points

• The research aims to explore the role of ginsenoside Rg5 in mitigating ferroptosis during ethanol-induced acute liver injury.
• Investigated the impact of ginsenoside Rg5 on ferroptosis in liver cells exposed to ethanol.
• Analyzed the activation of Nrf2 and other signaling pathways post-treatment with ginsenoside Rg5.
• Conducted biochemical assays to assess liver injury markers.
• Ginsenoside Rg5 significantly reduced markers of ferroptosis in liver cells.
• Nrf2 activation was observed following ginsenoside Rg5 treatment.
• Demethylation effects were noted, supporting ginsenoside's hepatoprotective action.