Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8 + T Cell Exhaustion and Ocular MALT Lymphoma Progression

Key Points

• The study aims to understand the role of IGLL5 mutations in BCR signaling and T cell exhaustion in ocular MALT lymphoma (OAML).
• Pharmacologic inhibition of BCR signaling was assessed.
• Combined BTK inhibitor and rituximab treatment was used.
• Evaluation of T cell phenotype and immune environment was conducted.
• Pharmacologic inhibition significantly suppressed IGLL5-associated BCR activation.
• Treatment indicated a reduction in T cell exhaustion phenotypes.
• Findings suggest IGLL5 signaling as a potential therapeutic vulnerability in OAML.