Spatial and temporal description of antimalarial drug resistance markers in Ghana using targeted amplicon deep sequencing

Key Points

• This research aims to describe the trends of antimalarial drug resistance markers in Ghana, particularly after the cessation of chloroquine use.
• Utilized targeted amplicon deep sequencing to analyze antimalarial resistance markers.
• Focused on chloroquine and sulfadoxine-pyrimethamine to assess molecular prevalence.
• Conducted a molecular surveillance study in malaria-endemic regions of Ghana.
• Observation suggests a return of chloroquine-sensitive parasites after two decades of disuse.
• Concerns about the efficacy of sulfadoxine-pyrimethamine markers for use in pregnancy and children were highlighted.
• Emphasis on the necessity of molecular surveillance to prevent artemisinin-resistant parasites from evolving.