Reply to Nguyen et al. Over-Intake of Plant-Derived Antioxidants, H2S Generation, and Reductive Stress. Comment on “Manzano-Pech et al. The Chronic Elevated Consumption of Hibiscus sabdariffa Linnaeus Results in Kidney Damage Associated with Excess H2S. Int. J. Mol. Sci. 2026, 27, 2190”

Key Points

• To address concerns about the effects of chronic Hibiscus sabdariffa consumption on oxidative stress and kidney damage.
• Chronic consumption of a 6% Hibiscus sabdariffa infusion for one month in healthy rats.
• Assessment of reactive oxygen species levels in the context of oxidative stress.
• Chronic Hibiscus sabdariffa infusion was shown to reduce levels of reactive oxygen species.
• Study contributes to understanding the balance of H2S generation and antioxidant capacity.