A Brain-Permeable Selenocyanate Near-Infrared (NIR) Probe Platform for H 2 S Dynamics Imaging: Insights into Redox Homeostasis and Antiepileptic Therapy

Key Points

• This research investigates the role of selenocyanate in neuroprotection and redox homeostasis related to epilepsy.
• Utilized a brain-permeable selenocyanate NIR probe platform for imaging H2S dynamics.
• Developed in-vivo biosensors based on a cyclization strategy for therapeutic monitoring.
• Analyzed redox homeostasis in the context of antiepileptic therapy.
• Demonstrated effective imaging of H2S dynamics within the brain.
• Established the significance of redox homeostasis in neuroprotection during epilepsy.
• Supported the development of advanced biosensors for broader biomedical applications.