Background: Many that experience heavy sweating also encounter irritation, whether from the sweat itself, skin friction or from antiperspirant (AP) products. Objective: To determine if a new caring clinical AP stick (Caring AP) could offer extra effective sweat protection while being gentle and caring to underarm skin. Methods: Several clinical studies were conducted comparing the caring AP versus an established sensitive therapeutic AP stick with 24-hour clinical strength protection (therapeutic AP). A standard 14-day cumulative irritation patch test (CIT) was completed. Additionally, a 24-hour short term moisturization (STM) study was performed, measuring skin hydration (Corneometer) and barrier function (Transepidermal Water Loss). Two hotroom studies were conducted, the first evaluated the extra effective performance over 96 hours of the caring AP and the second a comparison of the two products. Results: The 14-day CIT revealed that the caring AP is not significantly different from the therapeutic AP with both showing no significant irritation. However, the new caring AP delivered significantly increased hydration 4 hours post-application versus the therapeutic AP and improved barrier protection up to 24 hours following application compared to baseline. The hot room studies demonstrated the extra effectiveness of the caring AP at 96 hours and superior performance compared to the therapeutic AP at 72 hours. Conclusion: Traditionally, AP products with high levels of active have not been recommended for those prone to underarm irritation. However, this new caring AP has been developed to provide extra effective performance against sweat over 96 hours and while maintaining skin gentleness and conferring additional skincare benefits not observed by the therapeutic AP. This abstract was presented at the American Physiology Summit 2026 and is only available in HTML format. There is no downloadable file or PDF version. The Physiology editorial board was not involved in the peer review process.
Regan et al. (Fri,) studied this question.
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