May 15, 2026Scientific Reports0 citationsOpen Access
Hyaluronic acid/kaempferol-functionalized Fe₃O₄ nanoparticles promote ROS-associated apoptosis and modulate caspase-8/BCRT1 axis in triple-negative breast cancer
To investigate the effects of hyaluronic acid/kaempferol-functionalized Fe₃O₄ nanoparticles on apoptosis in triple-negative breast cancer cells.
Utilized functionalized Fe₃O₄ nanoparticles designed to target TNBC cells.
Analyzed the modulation of apoptosis markers and signaling pathways, including caspase-8 and BCRT1.
Demonstrated significant apoptosis induction via reactive oxygen species (ROS) signaling.
Notable modulation of caspase-8/BCRT1 axis was observed in treated TNBC cells.
Abstract
@Glu-HA-KAE NPs against TNBC cells, representing an innovative approach to combat TNBC.
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Hyaluronic acid/kaempferol-functionalized Fe₃O₄ nanoparticles promote ROS-associated apoptosis and modulate caspase-8/BCRT1 axis in triple-negative breast cancer | Synapse