The Influence of the Bone Scaffold Biodegradation Process on Bone Remodeling in Critical Size Bone Defects: A Finite Element Analysis

Key Points

• This research examines how the biodegradation of bone scaffolds affects bone remodeling in critical size defects.
• Finite element analysis was utilized to assess the biomechanical efficiency of scaffolds.
• Comparison of Young's modulus changes between different materials was conducted.
• V caused lower changes in average Young's modulus of callus compared to polymers, indicating material stiffness affects remodeling.
• Findings suggest that scaffold degradation must be considered in long-term design for biomechanical efficiency.