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Aims: To characterize the metabolic profiles associated with the Hepatic Insulin Resistance Index (HIRI), in Korean patients with type 2 diabetes mellitus. Methods: This cross-sectional study analyzed 2,475 Korean adults with type 2 diabetes from the Korean National Diabetes Program cohort. Participants were categorized into HIRI tertiles based on oral glucose tolerance tests. We examined associations between HIRI and anthropometric measures, glycemic parameters, lipid profiles, liver function markers, and dietary intake. Logistic regression assessed the risk of dyslipidemia and metabolic syndrome components, adjusting for relevant confounders. Results: < 0.0001). Conclusions: High hepatic insulin resistance in Korean patients with type 2 diabetes defines a phenotype characterized by central obesity, atherogenic dyslipidemia, and distinctive glycemic profiles. Recognition of this phenotype supports personalized diabetes management targeting hepatic IR.
Kim et al. (Thu,) studied this question.