Proton versus photon therapy for oropharyngeal cancer

Key Points

• To evaluate the effectiveness of proton therapy compared to photon therapy in treating oropharyngeal cancer.
• Randomized trial design
• Participants with diagnosed oropharyngeal cancer
• Assessed tumor control rates over a specified follow-up period.
• Proton therapy showed a 30% increase in tumor control rates compared to photon therapy, HR 0.75, 95% CI 0.60-0.90, P=0.02.
• Lower incidence of side effects was reported in the proton therapy group.
• Overall survival rates after two years were significantly higher in the proton therapy group.