Black women with peripartum cardiomyopathy experienced lower rates of ejection fraction recovery (40% vs 63%; P<0.0001) and higher mortality (8% vs 2%; P=0.013) compared with White women.
Meta-Analysis
Do Black women with peripartum cardiomyopathy experience worse clinical outcomes compared to White women in the United States?
Black women with peripartum cardiomyopathy in the US face significantly higher mortality and lower rates of LVEF recovery compared to White women, highlighting severe racial disparities in maternal cardiovascular outcomes.
Absolute Event Rate: 8% vs 2%
p-value: p=0.013
BACKGROUND: Peripartum cardiomyopathy (PPCM) is a leading cause of heart failure in pregnancy and contributes significantly to maternal morbidity and mortality. Black women are disproportionately affected and experience worse outcomes compared with other groups. OBJECTIVES: This study aimed to quantify differences in risk factors and outcomes between Black and White women in the United States diagnosed with PPCM. METHODS: statistics were utilized for analysis. RESULTS: Compared with controls, cases had higher rates of obesity, preeclampsia, hypertension, diabetes, multiple gestations, and tobacco use. Compared to White cases, Black cases had higher prevalence of diabetes (14% vs 5%; P = 0.027) and utilization of public payer (72% vs 30%; P < 0.001). At presentation, mean left ventricular ejection fraction was 26% in Black women and 29% in White women. White women experienced higher rates of recovery in ejection fraction (63% vs 40%; P < 0.0001). Mortality rates were higher among Black women (8% vs 2%; P = 0.013). CONCLUSIONS: Black women with PPCM experienced lower recovery and higher mortality rates compared with White women. With the exception of a significant difference in payer status, modest differences in previously identified risk factors were observed between racial groups to account for worse outcomes (Disparities in risk factors and outcomes between Black and White US women with peripartum cardiomyopathy: A systematic review and meta-analysis; CRD42023439228).
Hermans et al. (Mon,) conducted a meta-analysis in Peripartum cardiomyopathy. Black race vs. White race was evaluated on Mortality rates (p=0.013). Black women with peripartum cardiomyopathy experienced lower rates of ejection fraction recovery (40% vs 63%; P<0.0001) and higher mortality (8% vs 2%; P=0.013) compared with White women.