Organic piezoelectric materials, capable of converting mechanical stress into electrical signals and vice versa, are emerging as versatile platforms for biomedical applications. Their electromechanical behavior originates from ordered dipoles within non-centrosymmetric structures, found in polymers, biodegradable polyesters, polysaccharides, amino acids, ultrashort peptides, and fibrous proteins. The piezoelectric performance is strongly influenced by molecular design, chemical functionalization, crystalline phase, hierarchical organization, and processing techniques of those materials. Combining molecular engineering of amino acids and peptides with hierarchical polymer matrices promises tunable electromechanical properties, scalable fabrication, and biodegradable, bioresorbable platforms. These materials enable innovative biomedical technologies, including self-powered nanogenerators for implantable devices, wearable and implantable biosensors for real-time physiological monitoring, scaffolds that deliver localized electrical cues to promote tissue regeneration, and devices for smart drug-release. Collectively, organic piezoelectric materials offer a sustainable, biocompatible, and adaptable foundation for next-generation bioelectronics and regenerative medicine. • Organic piezoelectric materials enable next-generation wireless bioelectronics • Polymer–peptide hybrids drive high-performance piezoelectric systems • Polymer and peptide based piezoelectrics for smart biointerfaces and adaptive healthcare devices
Serrano-Bellido et al. (Fri,) studied this question.