AbstractIntramuscular immunoglobulin (IMIG) administered at a dose of 0.5 ml/kg is an option for prophylaxis in infants after exposure to measles. The weight-based dosing volumes require multiple or large-volume injections; however, no clear administration guidelines exist. In 2025, the Utah Department of Health and Human Services (DHHS) assisted with coordination of IMIG administration after an exposure event at a pediatric clinic. Utah DHHS worked with the local health department and health care facility to develop a plan for administration that has been used in subsequent exposure events in Utah.
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Angela Weil
Utah Department of Health
Anna Jones
Centers for Disease Control and Prevention
Kelly Mansfield
Intermountain Healthcare
NEJM Evidence
University of Utah
Centers for Disease Control and Prevention
Epidemic Intelligence Service
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Weil et al. (Wed,) studied this question.
synapsesocial.com/papers/6a08093ca487c87a6a40b2b2 — DOI: https://doi.org/10.1056/evidpha2600093