Uracil-BX-Enabled O -Uracilylation to Access 5-Aryloxy Uracils via Umpolung Strategy

Key Points

• This research aims to expand the synthetic applications of Uracil-BX in nucleobase transfer reactions.
• Utilized a cyclic hypervalent iodine reagent for uracilylation
• Explored various conditions for effective nucleobase transfer
• Assessed synthetic utility through reaction yield measurements.
• Successfully synthesized 5-aryloxy uracils via umpolung strategy
• Achieved improved yields compared to traditional methods
• Demonstrated the versatility of Uracil-BX scaffolds in nucleobase transfer.