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This study investigates the role of CX3CR1+ synovial macrophages in the context of hemophilic arthropathy.

May 16, 2026Journal of Thrombosis and Haemostasis0 citationsOpen Access

CX3CR1+ synovial macrophages accumulate in the joint during experimental hemophilic arthropathy but are not required for acute synovitis

ALAJ LawrenceTrinity College Dublin TMTatenda MurangiTrinity College Dublin ACAnne ChevalierTrinity College Dublin

Key Points

This study investigates the role of CX3CR1+ synovial macrophages in the context of hemophilic arthropathy.
Utilized knockout mice and the CX3CR1 antagonist AZD8797 for pharmacological inhibition.
Measured joint swelling after injury and performed histological assessments at Day 28 post-injury.
Macrophage recruitment was observed in experimental hemophilic arthropathy.
CX3CR1 antagonist treatment did not significantly alter hemophilic arthropathy development.
The CX3CL1-CX3CR1 axis was found to be dispensable for acute synovitis in this model.

Abstract

BACKGROUND: Hemophilic arthropathy (HA) is a chronic joint disease caused by repeated joint bleeding in patients with hemophilia (PWH), leading to joint degeneration despite prophylactic treatment. The CX3CL1(fractalkine)-CX3CR1 chemokine axis regulates synovial lining macrophage function and has been implicated in inflammatory joint diseases including rheumatoid arthritis and osteoarthritis. OBJECTIVES: macrophages in experimental hemophilic arthropathy using genetic targeting and pharmacological inhibition. METHODS: knockout mice and the CX3CR1 non-competitive allosteric antagonist AZD8797. Outcomes were measured by changes in joint swelling after injury and histological assessment at Day 28 after injury for hemosiderin deposition and synovitis. RESULTS: mice. Similarly, treatment with a CX3CR1 antagonist did not attenuate the development of HA. CONCLUSIONS: macrophage recruitment during experimental HA, the CX3CL1-CX3CR1 axis is dispensable for the pathogenesis of acute hemophilic synovitis in this mouse model of severe hemophilia A.

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