Design, synthesis, bioevaluation, and in silico insights of pyrazole-pyrrolinone and pyridazinone hybrids as potential antimicrobial agents

Key Points

• The research aims to design and synthesize novel pyrazole-pyrrolinone and pyridazinone derivatives for antimicrobial applications.
• Design and synthesis of pyrazole-pyrrolinone and pyridazinone derivatives
• Evaluation of antimicrobial and antibiofilm properties
• Mechanistic studies to identify lead compounds
• Identified several promising lead compounds with significant antimicrobial activity.
• Demonstrated reduced biofilm formation in specific derivatives.
• Mechanistic insights revealed pathways involved in antimicrobial efficacy.