Proton-pump inhibitor use is discussed as a potential modifiable etiological factor for iron deficiency in patients with heart failure.
Is proton-pump inhibitor use a modifiable etiological factor for iron deficiency in patients with heart failure?
Proton-pump inhibitor use is proposed as a modifiable etiological factor for iron deficiency in patients with heart failure.
Iron deficiency (ID) is highly prevalent in patients with heart failure (HF) and is associated with morbidity and worse prognosis, even without concomitant anaemia.1 The etiology of ID in HF seems multifactorial and consists of fixed (e.g. female sex) and modifiable factors (e.g. bowel congestion, inflammation and dietary intake).2 In HF, iron deficiency is often functional, mediated by inflammation-induced hepcidin upregulation, which reduces intestinal iron absorption and limits iron availability via ferroportin degradation.
Kutscher et al. (Fri,) conducted a editorial in Heart failure with iron deficiency. Proton-pump inhibitors was evaluated. Proton-pump inhibitor use is discussed as a potential modifiable etiological factor for iron deficiency in patients with heart failure.