Lactate-Sensitive Nanomachines for Enzyme-Controlled Drug Delivery in Cancer Therapy

Key Points

• The aim is to develop a novel enzyme-driven nanomachine for targeted drug delivery in cancer treatment.
• Preparing mesoporous silica nanoparticles with a cyclodextrin-lactate oxidase (CD-LOx) complex for drug delivery.
• Utilizing enzyme sensitivity to regulate the release of drug cargo in response to lactate levels.
• Demonstrated effective control of drug release in vitro under varying lactate concentrations.
• Achieved enhanced therapeutic effects in cancer cells due to targeted delivery.