Electrochemical Synthesis of 2-Oxa-bicyclo2.1.1hexanes by Anodic Oxidation-Cyclization Relay Strategy

Key Points

• The aim is to develop a general method for producing 2-oxa-bicyclo[2.1.1]hexanes from specific precursors.
• Utilized a novel electrosynthetic strategy involving anodic oxidation and cyclization.
• Focused on hydroxymethyl-substituted bicyclo[1.1.0]butanes as starting materials.
• Developed a protocol for direct functionalization of the target compounds.
• Successfully synthesized 2-oxa-bicyclo[2.1.1]hexanes in good yields.
• Demonstrated the potential for functionalizing the synthesized compounds with varied electrophiles.