What question did this study set out to answer?

This research aims to determine the effects of prelamin A in a specific mouse model on vascular health.

May 16, 2026Arteriosclerosis Thrombosis and Vascular Biology0 citations

Prelamin A in an Lmna L648R/L648R Mouse Model Does Not Promote Atherosclerosis or Vascular Smooth Muscle Loss

YWYuexia Wang LJLeroy C. Joseph CÖCecilia Östlund

Key Points

This research aims to determine the effects of prelamin A in a specific mouse model on vascular health.
Used an <i>Lmna</i> <sup>L648R/L648R</sup> mouse model with hyperlipidemia induced by a high-fat diet.
Assessed proliferation and apoptosis rates of aortic media cells at 52 weeks of age.
No significant differences in proliferation of aortic media cells were observed.
No significant differences in apoptosis of aortic media cells were observed.

Abstract

BACKGROUND: that lead to expression of an internally truncated, farnesylated prelamin A variant called progerin, which induces loss of vascular smooth muscle cells. Some studies have also reported that accumulation of full-length farnesylated prelamin A, which is normally completely processed to mature nonfarnesylated lamin A, can also drive vascular pathology during physiological aging. METHODS: mice that develop hyperlipidemia on a high-fat diet. RESULTS: mice at 52 weeks of age. There were no differences in proliferation or apoptosis of aortic media cells. CONCLUSIONS: mice.

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