Elevated hs-cTnT and NT-proBNP in hypertensive patients are associated with subclinical cardiac changes, such as a 0.61 mm increase in left atrial diameter (95% CI 0.09-1.13).
Observational
Are elevated levels of hs-cTnT and NT-proBNP associated with subclinical changes in cardiac structure and function in hypertensive patients?
Elevated hs-cTnT and NT-proBNP in hypertensive patients correlate with subclinical echocardiographic abnormalities, suggesting their potential utility in identifying early cardiac target organ damage.
in left ventricular mass index (95% CI 0.32-5.24), 3.61 cm/s in aortic valve velocity (95% CI 0.54-6.67), and 0.61 mm in left atrial diameter (95% CI 0.09-1.13). Elevated NT-proBNP levels were also associated with these structural changes, along with impaired diastolic function and arterial enlargement. Participants with the highest tertiles for both biomarkers had more pronounced cardiac structural and functional abnormalities, including increased interventricular septum thickness and worse diastolic function. Elevations in hs-cTnT and/or NT-proBNP are associated with subclinical changes in cardiac structure and function in hypertensive patients.
Wang et al. (Fri,) conducted a observational in Hypertension. High-sensitivity cardiac troponin (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) vs. Lower biomarker levels was evaluated on Echocardiographic features of cardiac structure and function. Elevated hs-cTnT and NT-proBNP in hypertensive patients are associated with subclinical cardiac changes, such as a 0.61 mm increase in left atrial diameter (95% CI 0.09-1.13).