This viewpoint focuses on core evidence regarding the cross-talk between adipose tissue inflammation and hepatic inflammation that possibly leads to the progression of metabolic dysfunction–associated steatotic liver disease to metabolic dysfunction–associated steatohepatitis, hepatic fibrosis, and cirrhosis. It is highlighted that the adipose tissue and hepatic inflammation increase in parallel with insulin resistance, possibly affecting each other, thereby leading to advanced liver disease. This interplay is partly mediated via adipokines produced by the adipose tissue, hepatokines produced by the liver, and cytokines produced by the immune cells infiltrating both the adipose tissue and the liver.
Vachliotis et al. (Wed,) studied this question.