Enantiocomplementary Synthesis of Chiral 2,3-Dihydroxy Aryl Ketones via ThDP-Dependent Enzymatic Catalysis

Key Points

• The aim is to develop a sustainable method for synthesizing chiral 2,3-dihydroxy aryl ketones.
• Utilized ThDP-dependent enzymes for biocatalysis.
• Coupled aryl aldehydes with unprotected glycolaldehyde.
• Successfully synthesized various chiral 2,3-dihydroxy aryl ketones.
• Demonstrated high enantiomeric excess in products.